Thalamic Nuclei Volumes in Multiple Sclerosis (THALNUC-MS)

University Hospital of Bordeaux

Status: Unknown

Conditions: Multiple Sclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT05002764

CHUBX 2021/33

Details and patient eligibility

About

The thalamus is composed of several nuclei interlocked in a complex anatomy. In multiple sclerosis (MS), the thalamus can be altered due to disconnection by white matter lesions and due to direct damages that could be partly mediated by CSF. Due to such pathophysiology and complex anatomy, some nuclei could be more vulnerable to multiple sclerosis than others. We will test this hypothesis by using a new algorithm to automatically segment several nuclei that we will be applied to the French national MS database

Enrollment: 2,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria :

• Patient older than 18 years old.
• With Multiple Sclerosis according to Mc Donald 2017 criteria or with clinically isolated syndrome and included with OFSEP cohort.
• Phenotype known (RR, SP, PP or CIS).
• Date of diagnosis known.
• With at least one MRI that includes 3D T1 and FLAIR at 1.5T or 3T.

Exclusion Criteria :

• Stroke
• Other causes of dementia not caused by Multiple Sclerosis (Alzheimer's disease, Parkinsonian syndromes...)