The Acute Effect of Atorvastain on Renal Function in Patients With Type II Diabetes

Regional Hospital Holstebro

Status and phase: Completed; Phase 4

Conditions: Healthy Subjects

Treatments: Drug: Atorvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT00678522

MED.RES.HOS.2006.04.LP

Details and patient eligibility

About

We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium excretion, glomerular filtration rate, tubular function and vasoactive hormones in patients with type II diabetes, not in treatment with insulin.

Enrollment: 25 estimated patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age: 40-70 yrs
2. estimated GFR between 30 and 90 ml/min
3. BMI<35
4. Fertile women had to use oral contraceptives or IUD
5. HbA1c< 10%
6. Urine-albumin<1,5 g/l

Exclusion criteria

1. Treatment with insulin
2. Cerobrovascular insult or other disease of the brain
3. Insufficiency of the heart or lungs
4. Liverdisease with ALAT > 200 U/L
5. hemoglobin < 7,0 mmol/l
6. Cancer
7. Alcohol abuse
8. Medical treatment with psycopharmaca or/and analgetics
9. Pregnancy and breast feeding, 10 blood donation one month before the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind