The Acute Effect of Egg-Based High Protein Meal on Hypertensive Response to Exercise (S47)

Purdue University

Status: Completed

Conditions: Cardiovascular Risk Factor; Blood Pressure

Treatments: Other: HIgh Protein; Other: Normal Protein

Study type: Interventional

Funder types: Other

Identifiers

NCT03073252

1607017949

Details and patient eligibility

About

The primary purpose of this study is to explore the effect of high versus normal egg-based protein meals on acute exercise-induced elevated blood pressure.

Full description

This study is designed to assess BP changes during and post- exercise after consumption of a test breakfast. The design consists of three visits. The first visit will assess each participants aerobic exercise capacity (VO2 max). Visit 2 and 3 will be clinical testing days where the subject will consume either the 13g or 30g protein breakfast in a randomized cross-over manner and perform the exercise intervention. BP changes will be monitored before and after breakfast consumption, during the exercise intervention,

Enrollment: 31 patients

Sex: All

Ages: 21 to 121 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pre-hypertensive (systolic, 120-139 mm Hg; diastolic, 80-89 mm Hg
• Age ≥ 21
• Body weight <300 lb (136 kg)
• BMI between 20 and 34.9 kg/m2
• Fasting plasma glucose <6.1 mmol/L,
• total cholesterol <6.7 mmol/L
• LDL cholesterol <4.1 mmol/L
• TG <4.5 mmol/L
• No pre-existing or history of cardiovascular, renal or liver disease
• Not currently or previously (past 6 mo) consuming a weight-loss diet or other special/non-balanced diets
• No weight loss/gain (±4.5 kg) within the past 6 mo
• No physical impairments preventing properly exercise execution
• No caffeine intake the day of testing

Exclusion criteria

• Hypertensive
• Body weight ≥ 300 lb
• BMI <20 or >35 kg/m2
• Pregnant or planning pregnancy
• Unwilling to consume study foods and beverages
• Fasting plasma glucose ≥6.1 mmol/L
• Total cholesterol ≥6.7 mmol/L
• LDL cholesterol ≥4.1 mmol/L
• TG ≥4.5 mmol/L
• acute illness
• smoking
• diabetic
• pre-existing or history of cardiovascular, renal or liver disease
• currently or previously (past 6 mo) consuming a weight-loss diet or other special/non-balanced diets
• weight loss/gain (±4.5 kg) within the past 6 months
• physical impairments preventing properly exercise execution
• caffeine the day of testing

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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31 participants in 2 patient groups

Normal Protein

Experimental group

Description:

Consumption of normal protein (NP) meal

Treatment:

Other: HIgh Protein

Other: Normal Protein

High Protein

Experimental group

Description:

Consumption of high protein (HP) meal

Treatment:

Other: HIgh Protein

Other: Normal Protein