The Acute Effect of Exercise on Appetite Appetite-regulating Hormones and Inflammation in Children

University of Toronto

Status

Completed

Conditions

Obesity

Treatments

Other: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT02619461

HIT_Exercise_Appetite_001

Details and patient eligibility

About

This study describes the effect of acute high intensity exercise at 70% VO2peak on inflammation, stress, appetite hormones and appetite in lean and obese children and adolescents.

Full description

In summary, exercise does induce a variety of metabolic mechanisms on a central and peripheral level, related to appetite other than solely gut peptides. The literature points towards a rather loose coupling when it comes to high intensity exercise and the suppression of food intake, without a clear explanation of the cause of exercise induced anorexia. This study is aimed to investigate high-intensity exercise and its effects on appetite and satiety hormones, inflammation, stress and eating behaviors on appetite and food intake.

The objective of the current study is to investigate the factors contributing to exercise-induced anorexia in lean and obese children, and maximize its translation into post-exercise suppression of food intake and promotion of negative energy balance particularly in obese children. It is hypothesized that high-intensity exercise would promote a greater suppression of food intake through suppression of appetite ratings via physiological mechanisms depending on stress and inflammation rather than gut peptides.

Enrollment

22 patients

Sex

Male

Ages

10 to 18 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

11 normal weight and 11 obese boys will be recruited for the study. Lean and obese boys aged 10-18 years, born full-term and with a normal body weight at birth, will be included in the study

Exclusion criteria