The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal

University of the Highlands and Islands

Status: Completed

Conditions: Endothelial Dysfunction

Treatments: Other: Orange Juice; Other: Water; Other: Red Wine; Other: Green Tea

Study type: Interventional

Funder types: Other

Identifiers

NCT03806829

ETHSHE1376

Details and patient eligibility

About

High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress.

Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.

Enrollment: 7 patients

Sex: All

Ages: 50 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Females to be postmenopausal and not on hormone replacement therapy
• 25 > BMI < 35
• Sedentary to light activity lifestyle.

Exclusion criteria

• History of cardiovascular disease (Hypertension, Atherosclerosis, endothelial issues etc).
• History of diabetes (Type 1 or type 2)
• Vegan or with food allergies or intolerances.
• Taking any antioxidants over the counter (Vit C, E or polyphenol supplements)
• Taking prescription medication for hypertension.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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7 participants in 4 patient groups

Water + Meal

Active Comparator group

Description:

250 ml Water and a high calorie, high fat meal (\>900 kcal, 50g fat)

Treatment:

Other: Water

Red Wine + Meal

Experimental group

Description:

250 ml Red Wine and a high calorie, high fat meal (\>900 kcal, 50g fat)

Treatment:

Other: Red Wine

Green Tea + Meal

Experimental group

Description:

250 ml Green Tea and a high calorie, high fat meal (\>900 kcal, 50g fat)

Treatment:

Other: Green Tea

Orange Juice + Meal

Experimental group

Description:

250 ml Orange Juice and a high calorie, high fat meal (\>900 kcal, 50g fat)

Treatment:

Other: Orange Juice