The Acute Effects of Meals Rich in Saturated or Unsaturated Fatty Acids on Postprandial Lipaemia in Healthy Men (CocoHeart)

University of Reading

Status: Completed

Conditions: Cardiovascular Risk Factor

Treatments: Dietary Supplement: Coconut oil; Dietary Supplement: Butter; Dietary Supplement: Vegetable oil

Study type: Interventional

Funder types: Other

Identifiers

NCT05264233

19/30

Details and patient eligibility

About

Current dietary recommendations suggest that lowering intake of saturated fats or replacing it with unsaturated fats will decrease the risk of developing cardiovascular disease. Coconut oil has gained popularity in recent years but it contains 90% saturated fat, which has higher percentage of saturated fat than butter. To date, only limited studies have determined the acute effects of meals containing coconut oil on blood lipids, but findings are inconsistent. Therefore, further studies are needed to address this knowledge gap and compare the postprandial effects of test meals rich in coconut oil with other sources of saturated fatty acids such as butter and unsaturated fatty acids (vegetable oils). A cross-over, double-blind, randomised acute postprandial study will be conducted in 15 healthy men. Participants will be assigned to consume the test meals rich in saturated or unsaturated fatty acids in random order on 3 separate occasions, with 3-4 weeks between each study visit. Participants will be provided with breakfast (toast with jam and milkshake, 50g fat) and lunch (toast with jam and milkshake, 30g fat). The anthropometric, blood pressure, arterial stiffness, and breath samples will be taken for each study visit. Blood samples will be collected for the measurement of fasting lipids, glucose, insulin, inflammatory markers, whole blood culture as well as blood clotting. Breath samples are collected for the measurement of gastric emptying as well as assessment of satiety using questionnaires (100 mm visual analogue scale) completed throughout the day. The findings from this study will contribute to the evidence base on how consuming meals rich in coconut oil influence the level of blood lipids as well as other biomarkers for cardiovascular disease.

Enrollment: 13 patients

Sex: Male

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men
• Aged between 30 to 70 years
• Serum triacylglycerol < 2.3 mmol/l
• Body mass index between 19-32 kg/m2
• Total cholesterol < 7.5 mmol/l

Exclusion criteria

• Females
• Smokers
• Medical history of myocardial infarction or stroke in the past 12 months
• Diabetes (defined as fasting glucose > 7.0 mmol/l) or other endocrine disorders
• Kidney, liver, pancreas or gastrointestinal disorder
• Hypertension (blood pressure > 140/90 mmHg), cancer, medication for hyperlipidaemia (e.g. statins), hypertension or, inflammation
• Anaemia (<130 g/L haemoglobin)
• Taking any dietary supplements known to influence lipids/gut microbiota (e.g. plant stanols, fish oil, phytochemicals, natural laxatives, probiotics and prebiotics)
• Drinking in excess of 14 units of alcohol per week
• Planning on a weight-reducing regime
• Parallel participation in another dietary intervention study
• Any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention and metabolic study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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13 participants in 3 patient groups

Meal rich in coconut oil

Active Comparator group

Description:

Participants will be asked to consume a breakfast (0 minute) and lunch (330 minute) rich in coconut oil

Treatment:

Dietary Supplement: Coconut oil

Meal rich in butter

Active Comparator group

Description:

Participants will be asked to consume a breakfast (0 minute) and lunch (330 minute) rich in butter

Treatment:

Dietary Supplement: Butter

Meal rich in vegetable oil

Active Comparator group

Description:

Participants will be asked to consume a breakfast (0 minute) and lunch (330 minute) rich in vegetable oil

Treatment:

Dietary Supplement: Vegetable oil