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The Acute Effects of Passive Vibration on Cardiovascular Function in Individuals With Stroke

Florida State University logo

Florida State University

Status

Completed

Conditions

Hypertension
Stroke
Pre-Hypertension
Hemiparesis

Treatments

Other: Low-Frequency Passive Vibration
Other: High-Frequency Pasive Vibration

Study type

Interventional

Funder types

Other

Identifiers

NCT01841840
2012.7712

Details and patient eligibility

About

Stroke is the third leading cause of death in the United States. Of those who are affected by stroke, a third becomes permanently disabled. Risk factors for stroke include, but are not limited to, advancing age, physical inactivity, arterial stiffness, and most commonly, high blood pressure. Stroke is a major form of a much boarder problem, cardiovascular disease (CVD). CVD is considered the primary cause of death in the US. Interestingly, increased arterial stiffness of elastic arteries (carotid and aorta) has been shown to be strongly correlated to CVD and stroke. Increased arterial stiffness is considered an independent risk for the development of CVD and stroke. Hence, arterial stiffness has been suggested as a potential therapeutic target for CVD and more specifically stroke.

Recently, whole-body vibration (WBV) exercise has been proposed as a new and effective method to improve muscle mass and muscle strength in younger and older individuals. It is known that systemic arterial stiffness decreased 40 min after a single WBV session in healthy men. In our laboratory, we have shown that leg arterial stiffness decreases after a session of WBV. Taken together, this data seems to suggest WBV may be used as a viable way to decrease arterial stiffness. Special populations, such as post-stroke patients, may be unwilling or unable to perform WBV exercise so an inactive form of exercise (vibration) therapy is needed.

Passive vibration (PV), allows patients to lie in an inactive, supine position, with their legs placed onto the vibration plate. This exposes the lower limbs to continuous vibration without performing voluntary muscle contraction. PV has been shown to increase skin blood flow on the vibrated extremity through vasodilation in healthy individuals and type 2 diabetics. Previous work in our laboratory has demonstrated that a 10-min session of PV on the legs decreases augmentation index (AIx) , a marker of pressure wave reflection, as well as leg and systemic PWV through decreases in local peripheral resistance in young men. However, the effects of PV on arterial function in post-stroke patients are unknown.

It is hypothesized that post-stroke patients will demonstrate a decrease in leg PWV and central AIx. However, greater responses are expected with the lower vibration frequency.

Full description

The purpose of this study is to examine the effects of one acute bout of low and high frequency passive vibration on blood pressure, heart rate, arterial stiffness, wave reflection, and autonomic function in post-stroke patients.

The specific aim of this study is:

-To evaluate the effects of an acute bout of both high (40Hz/low amplitude) and low frequency (25Hz/high amplitude) passive vibration on arterial function and aortic hemodynamics by assessing blood pressures (systolic, diastolic, mean, pulse pressure), arterial stiffness (aortic, systemic, leg), aortic wave reflection (augmentation index), and autonomic function (heart rate variability).

Enrollment

11 patients

Sex

All

Ages

40 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 40-80 years of age
  • Resting Blood Pressure between 120/80 and 159/99
  • Non-Smoker
  • Sedentary or low activity (<120 min per week)
  • 25-39.9 kg/m2 BMI
  • Diagnosed with stroke for at least 4 months

Exclusion criteria

  • Younger than 40 and older than 80 years of age
  • Resting Blood Pressure below 120/80 or above 159/99
  • Smoker
  • Physically active
  • BMI below 25 kg/m2 or above 39.9 kg/m2
  • Diagnosed with stroke for less than 4 months
  • Diagnosed with any other cardiovascular diseases besides stroke and stage-1 hypertension

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

11 participants in 3 patient groups

Control
No Intervention group
Description:
This arm involves not implementing any form of intervention (passive vibration)on the subject during this visit.
Low-Frequency Pasive Vibration
Experimental group
Description:
This arm involves exposing the subject to a 10 minute session of passive vibration set to a frequency of 25Hz and a high amplitude.
Treatment:
Other: Low-Frequency Passive Vibration
High-Frequency Passive Vibration
Experimental group
Description:
This arm involves exposing the subject to a 10 minute session of passive vibration set to a frequency of 40Hz and a low amplitude.
Treatment:
Other: High-Frequency Pasive Vibration

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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