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The Addition of Inhaled Furosemide to Standard Treatment of COPD Exacerbation (FUROSCOPE)

A

American University of Beirut Medical Center

Status and phase

Not yet enrolling
Phase 3

Conditions

Chronic Obstructive Pulmonary Disease Exacerbation
COPD Exacerbation

Treatments

Drug: Furosemide
Drug: Normal saline

Study type

Interventional

Funder types

Other

Identifiers

NCT05769738
BIO-2022-0187

Details and patient eligibility

About

The goal of this randomized controlled trial is to determine the effect of adding inhaled furosemide to the known treatment of patient with Chronic obstructive pulmonary disease (COPD) exacerbation. It primarily aims at studying its effect on:

  1. Relief of dyspnea sensation
  2. Length of hospital stay

Participants will be receiving the standard therapy of COPD exacerbation plus either inhaled furosemide or inhaled saline over 3 days. They will be asked to:

  • Perform spirometry
  • Fill in dyspnea score
  • Do arterial blood gases (ABGs)

Enrollment

200 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age ≥ 18 years
  • Diagnosed with COPD
  • Presenting with COPD exacerbation
  • Requiring hospitalization

Exclusion criteria

  • Hemodynamically instability (systolic blood pressure ≤ 90mmHg, heart rate ≥ 120 or ≤ 50 Bpm)
  • Decreased level of consciousness
  • Non-invasive mechanical ventilation or intubation at the time of recruitment
  • >5 liters of oxygen at the time of recruitment
  • Pregnant patients
  • Other primary pulmonary disease or heart failure exacerbation

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

200 participants in 2 patient groups, including a placebo group

Furosemide group
Experimental group
Description:
Inhaled furosemide
Treatment:
Drug: Furosemide
Placebo group
Placebo Comparator group
Description:
Inhaled saline
Treatment:
Drug: Normal saline

Trial contacts and locations

0

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Central trial contact

Hisham Bou Fakhreddine, MD; Nivine Abou Dargham, MD

Data sourced from clinicaltrials.gov

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