The Advancing Dynamic And Personalized Training Study

University of Wisconsin (UW)

Status: Enrolling

Conditions: Well-Being, Psychological

Treatments: Other: Healthy Minds Program (HMP) app

Study type: Interventional

Funder types: Other

Identifiers

NCT07051330

A171600 (Other Identifier)

2025-0660

Details and patient eligibility

About

This study aims to enhance the Healthy Minds Program (HMP) app by developing and testing a personalized, data-driven approach to optimize long-term well-being. 1100 participants will be enrolled and on study for up to 4 months (4 week intervention plus 3 month follow-up).

Full description

Participants will be randomly assigned to various training conditions that vary across six factors. Each of the six factors is binary ("yes" vs. "no"), and for each factor there is a 50 percent probability of assignment to either level.

1. Introduction video for the app (yes / no)
2. Introduction video for the training modules (yes / no)
3. Module order based on ACIP score (highest-first / lowest-first)
4. Practice-nudging text messages (yes / no)
5. Microsupport messages during the intervention period (yes / no)
6. Microsupport messages during the follow-up period (yes / no)

Participants will take surveys at baseline, weekly through the 4-week intervention, and 3-month follow-up.

Enrollment: 1,500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Elevated symptoms of depression (PHQ-9 greater than or equal to 5)
• proficiency in English
• access to a smartphone and internet
• ability to receive text messages

Exclusion criteria

• Prior experience with meditation
• Prior use of the Healthy Minds Program app
• History of psychosis or mania
• Plans to travel in the next six weeks
• Suicidal ideation or thoughts of self-harm indicated by PHQ-9 item 9 and BDI item 9
• Failure to select the correct code word mentioned in the welcome video
• Not a US citizen
• Non-permanent resident
• Self-identification as artificial intelligence (AI)
• Has a hearing impairment

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

---

1,500 participants in 6 patient groups

Introduction Video to HMP app

Experimental group

Description:

All participants are randomized to this condition (Yes or No)

Treatment:

Other: Healthy Minds Program (HMP) app

Introduction Video to Training Modules

Experimental group

Description:

All participants are randomized to this condition (Yes or No)

Treatment:

Other: Healthy Minds Program (HMP) app

Module Order based on ACIP Score

Experimental group

Description:

All participants are randomized to this condition (Highest score first or Lowest score first)

Treatment:

Other: Healthy Minds Program (HMP) app

Practice-Nudging Test Messages

Experimental group

Description:

All participants are randomized to this condition (Yes or No)

Treatment:

Other: Healthy Minds Program (HMP) app

Microsupport Messages During Intervention

Experimental group

Description:

All participants are randomized to this condition (Yes or No)

Treatment:

Other: Healthy Minds Program (HMP) app

Microsupport Messages During Follow-Up

Experimental group

Description:

All participants are randomized to this condition (Yes or No)

Treatment:

Other: Healthy Minds Program (HMP) app