The Adverse Drug Reaction (ADRe) Profile for Polypharmacy (ADRe-p)

Swansea University

Status: Completed

Conditions: Polypharmacy

Treatments: Other: Adverse Drug Reaction ADRe Profile for Polypharmacy

Study type: Interventional

Funder types: Other

Identifiers

NCT03955133

SwanseaNursing

Details and patient eligibility

About

Polypharmacy, the use of multiple or inappropriate medications, has the potential to harm older adults by causing cognitive impairment, falls, and hospitalisations. The nurse-led intervention (The ADRe Profile) to review mental health medicines has demonstrated improved care quality by: identifying serious adverse drug reactions (ADRs); reducing prescription of mental health medicines; reducing the prevalence of pain and nausea; and, increasing non-urgent national health service (NHS) contacts. The investigators will develop ADRe to encompass medicines commonly prescribed in primary care and evaluate intervention implementation in care homes in Aneurin Bevan University Health Board.

Full description

The investigators will introduce medicines' monitoring using the PADRe Profile into up to 7 care homes, each with up to 26 residents prescribed >4 medicines (estimated ~90% residents).

Each home will identify a nurse lead and a deputy. Nurses will be asked to administer the PADRe Profile with all patients prescribed >4 medicines.

Barriers, facilitators, and feasibility of the Profile will be explored. This will identify how, in which contexts medicines' monitoring can be integrated into routine care, relate the Profile to improved processes and outcomes of care, and inform implementation strategies (see logic model in cited papers).

Data collection:

• Record review before and after each of 3 administrations of the intervention to identify clinical and prescription changes. Narrative accounts of problems causing moderate or severe harm will be prepared.
• Serial interviews and debriefs with nurses: three per nurse.
• Stakeholder interviews with patients, participating pharmacists and prescribers for an overview of implementation.

Enrollment: 19 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Resident at the care home and expected to continue to live there for 1 year

  • Currently taking >3 prescribed medicines daily
  • Willing and able to give informed, signed consent themselves, or where capacity is lacking, a consultee is willing to give advice and assent to the resident participating.

Exclusion criteria

• age <18

  • Prescribed <4 medicines daily;
  • Receiving active palliative care
  • Not well enough to participate, as screened by their nurses

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

intervention

Experimental group

Description:

This is a single arm before and after study with data collection at 4 time points.

Treatment:

Other: Adverse Drug Reaction ADRe Profile for Polypharmacy