The Age-related Changes of Energy Metabolism in Physically Fit Adult Males

Poznan University of Physical Education

Status: Completed

Conditions: Healthy

Treatments: Diagnostic Test: Cardio-pulmonary exercise test

Study type: Interventional

Funder types: Other

Identifiers

NCT05113914

AWF_LA_MA865862

Details and patient eligibility

About

The influence of age and physical fitness level on the level of energy metabolism and antioxidant capacity in adult males.

Full description

Over four hundred healthy, adult males of different age categories and physical fitness levels were included in the study. There is much research convincing that in athletes of various sports disciplines the level of energy metabolism, oxidative stress, and amino acid profiles during years of training undergoes sports adaptation. The study aimed to evaluate how age and physical fitness level affects the level of purine metabolites and metabolites of nicotinamide adenine dinucleotide, the level of antioxidant capacity, and amino acid profiles. Investigators hypothesized that there will be an age-related decline in most of the physiological indices, but significant differences will appear regarding the level of an individual's sports adaptation.

Enrollment: 420 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. healthy
2. non-smoking
3. physically fit, including top-level athletes

Exclusion criteria

1. no reported history of a cardiopulmonary or renal diseases, and other chronic diseases
2. no major orthopedic injury or illness resulting in an inability to run
3. no medications that could affect cardiopulmonary functions
4. normal resting electrocardiogram
5. body mass index (BMI) below 30.0 kg·m-2
6. normal erythrocyte count and Hb content
7. no pathological states known of significantly elevated adenylate pool and concentration of ATP, e.g. sickle cell disease, diabetes, leukemia, sepsis, tuberculosis, meningococcal infection, or renal insufficiency

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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420 participants in 1 patient group

Healthy, physically fit men

Experimental group

Description:

All participants underwent a single CPET test with pre- and post-exercise blood measurements.

Treatment:

Diagnostic Test: Cardio-pulmonary exercise test