The AID Study: Artificial Intelligence for Colorectal Adenoma Detection

Istituto Clinico Humanitas

Status

Completed

Conditions

Colon Cancer

Treatments

Other: AI

Study type

Observational

Funder types

Other

Identifiers

NCT04079478

2363

Details and patient eligibility

About

Colonoscopy is clinically used as the gold standard for detection of colon cancer (CRC) and removal of adenomatous polyps. Despite the success of colonoscopy in reducing cancer-related deaths, there exists a disappointing level of adenomas missed at colonoscopy. "Back-to-back" colonoscopies have indicated significant miss rates of 27% for small adenomas (< 5 mm) and 6% for adenomas of more than 10 mm in diameter. Studies performing both CT colonography and colonoscopy estimate that the colonoscopy miss rate for polyps over 10 mm in size may be as high as 12%. The clinical importance of missed lesions should be emphasized because these lesions may ultimately progress to CRC8.

Limitations in human visual perception and other human biases such as fatigue, distraction, level of alertness during examination increases such recognition errors and way of mitigating them may be the key to improve polyp detection and further reduction in mortality from CRC. In the past years, a number of CAD systems for detection of polyps from endoscopy images have been described. However, the benefits of traditional CAD technologies in colonoscopy appear to be contradictory, therefore they should be improved to be ultimately considered useful. Recent advances in artificial intelligence (AI), deep learning (DL), and computer vision have shown potential to assist polyp detection during colonoscopy.

Enrollment

700 patients

Sex

All

Ages

40 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All 40-80 years-old subjects undergoing a colonoscopy.

Exclusion criteria

subjects with personal history of CRC, or IBD.
patients with inadequate bowel preparation (defined as Boston Bowel Preparation Scale > 2 in any colonic segment).
patients with previous colonic resection.
patients on antithrombotic therapy, precluding polyp resection.
patients who were not able or refused to give informed written consent.