The Aim of the Study is to Check Whether Follicular Fluid Evaluation Using a Spectrophotometer Can Differentiate High Quality Oocytes From Low Quality Oocytes. Oocyte Quality Will be Defined Using GDF9, BMP15 and Oocyte Morphology.

Hillel Yaffe Medical Center

Status: Active, not recruiting

Conditions: Oocyte Quality Assessment Using Spectrophotometer

Treatments: Procedure: Oocyte quality assessment using spectrophotometer

Study type: Interventional

Funder types: Other

Identifiers

NCT07329998

0069-23-HYMC

Details and patient eligibility

About

The aim of the study is to check whether follicular fluid evaluation using a spectrophotometer can differentiate high quality oocytes from low quality oocytes. Oocyte quality will be defined using GDF9, BMP15 and oocyte morphology. The correlation between cortisol levels in women and oocyte quality parameters will be estimated.

Enrollment: 200 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women aged 20-40 years.
• Undergoing IVF or IVF-ICSI treatment.
• At least five follicles visualized on ultrasound at the time of oocyte retrieval
• Ability to provide written informed consent.

Exclusion criteria

• Age >40 years.
• Fewer than five follicles at the time of oocyte retrieval.
• Use of donor oocytes.
• Significant medical comorbidities affecting ovarian function.
• Known ovarian malignancy or prior ovarian surgery significantly affecting follicular integrity.

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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200 participants in 1 patient group

follicular fluid evaluation using spectrophotometer to differentiate high low quality oocytes

Experimental group

Treatment:

Procedure: Oocyte quality assessment using spectrophotometer