The Aim of This Investigation is to Compare the Influence of 0.9% Saline and Plasmalyte Solution on Acid-base Balance and Electrolytes in Healthy Patients Undergoing Major Spine Surgeries.
Status
Completed
Conditions
Spinal Surgery
Treatments
Other: plasmalyte
Other: 0.9% normal saline
Details and patient eligibility
About
Chloride-rich isotonic crystalloid solutions have been shown to exert electrolyte imbalance and metabolic acidosis in critically ill patients. The aim of this investigation is to compare the influence of 0.9% saline and plasmalyte solution on acid-base balance and electrolytes in healthy patients undergoing major spine surgeries.
Enrollment
50 patients
Sex
All
Ages
20 to 70 years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
1.50 patients (aged 20-65) undergoing cervical or lumbar spine surgery who were diagnosed spinal stenosis involving more than tow spinal levels.
Exclusion criteria
- ASA class III or IV
- pregnancy
- breast feeding
- lack of mental weakness(including disabled)
- using diuretics
- respiratory insufficiency
- metabolic acidosis or alkalosis
- coagulation disorder
- over hydtration
- renal failure or serum creatinine > 1.4mg/dl
- anemia (Hemoglobin 9.0<mg/dl)
- hypernatremia (Na > 145mEq/L)
- Hyperkalemia (K>5.5mEq/L)
- psychological medication or any drugs that influences renal clearance
Trial design
Primary purpose
Prevention
Allocation
Randomized
Interventional model
Parallel Assignment
Masking
Single Blind
50 participants in 2 patient groups
0.9% saline
Experimental group
Description:
In each group, patients received either 0.9% normal saline or plasmalyte solution until end of surgery.
Treatment:
Other: 0.9% normal saline
plasmalyte
Active Comparator group
Description:
In each group, patients received either 0.9% normal saline or plasmalyte solution until end of surgery.
Treatment:
Other: plasmalyte
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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