The Anabolic and Catabolic Effect of Loaded and Unloaded Exercise on Articular Cartilage Health

University of Manitoba

Status: Completed

Conditions: Healthy

Treatments: Other: -12% Body Mass; Other: +12% Body Mass; Other: Control Condition

Study type: Interventional

Funder types: Other

Identifiers

NCT05925244

HS22322

Details and patient eligibility

About

The serum concentration of cartilage oligomeric matrix protein (sCOMP) has been considered a mechano-sensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP) is a proposed biomarker of type II collagen synthesis. Few studies have investigated both the anabolic and turnover response of articular cartilage as a result of acute changes in body weight mass during exercise. Using a repeated measures cross-over design, fifteen healthy adults (age 18-30 years) performed three, 30-minute bouts of treadmill walking exercise under 3 loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 minutes after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP).

Enrollment: 15 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• 18-30 years old

Exclusion criteria

• Traumatic injury to the lower extremity in the past year
• Hip, knee, or ankle surgery
• Radiographic evidence of joint degeneration
• Cardiovascular disease
• Ankylosing spondylitis
• Psoriatic arthritis
• Chronic reactive arthritis
• Renal problems requiring peritoneal dialysis or hemodialysis
• Not currently using any prescription or non-prescription medications and/or nutritional supplements

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 3 patient groups

Control

Experimental group

Description:

The control condition did 30 minutes of walking exercise with their own body mass.

Treatment:

Other: Control Condition

+12% Body Mass

Experimental group

Description:

The +12% body mass condition did 30 minutes of walking exercise wearing a weighted vest with +12% of their body mass applied.

Treatment:

Other: +12% Body Mass

-12% Body Mass

Experimental group

Description:

The -12% body mass condition did 30 minutes of walking exercise using a lower body positive pressure treadmill with -12% of their body mass applied.

Treatment:

Other: -12% Body Mass