The Analgesic Efficacy of Oxycodone Hydrochloride Versus Fentanyl After Total Hip Arthroplasty:

Al-Azhar University

Status and phase: Completed; Phase 4

Conditions: Total Hip Arthroplasty; The Analgesic Efficacy

Treatments: Drug: propofol, rocuronium and fentanyl

Study type: Interventional

Funder types: Other

Identifiers

NCT05602519

IRB 00012367-22-010-005

Details and patient eligibility

About

Oxycodone showed similar or superior analgesic effects than fentanyl and was proposed as an alternative for fentanyl for pain control in the postoperative period. However, it was mainly directed to control visceral pain, due to the mediation of analgesic effects by the kappa receptors. However, few studies compared the oxycodone to fentanyl for postoperative pain relief in patients undergoing total hip arthroplasty (replacement). Therefore, we established this randomized study to compare the efficacy of oxycodone and fentanyl for relief of postoperative pain after total hip arthroplasty (replacement).

Enrollment: 72 patients

Sex: All

Ages: 28 to 62 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 28-62 years old,
• Both genders, American Society of Anesthesiologists (ASA) physical status classification I or II who scheduled for elective total hip surgery.

Exclusion criteria

• Patients with history of any kind of drug allergy.
• drug abuse.
• psychological or other emotional problems,
• renal and hepatic chronic disease.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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72 participants in 2 patient groups

Group fentanyl

Active Comparator group

Description:

Patients will receive 50 ug of fentanyl 20 min before the end of surgery.

Treatment:

Drug: propofol, rocuronium and fentanyl

Group oxycodone

Active Comparator group

Description:

Patients will receive 4 mg of oxycodone 20 min before the end of surgery.

Treatment:

Drug: propofol, rocuronium and fentanyl