The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

Al-Azhar University

Status: Completed

Conditions: Dental Caries

Treatments: Other: Miswak; Other: fluoride; Other: Grape Seed Extract Mouthwash

Study type: Interventional

Funder types: Other

Identifiers

NCT04136639

REC17-082

Details and patient eligibility

About

Prevention of dental caries has taken a great importance in the last decade. The use of herbal and natural products became mandatory to avoid the side effects of commercially available medications. Aim of the study; the aim was to investigate the anti-cariogenic effect of miswak and grape seed extract (GSE).

Full description

Patients used Miswak sticks, grape seed extract mouth wash and fluoride mouthwash twice daily for three month. Saliva samples were collected at base line and after one month and three month. Assessment of bacterial count and saliva buffering capacity were performed at base line and after one and three month.

Enrollment: 30 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with high caries risk
• Males or females
• Medically free patients
• Patients approving to participate in the study

Exclusion criteria

• Patients who were on antibiotic therapy or corticosteroid therapy for 30 days before the examination
• Patients had history of professional cleaning in the last 15 days
• Patients with exposed pulp
• Evidence of parafunctional habits
• Patients with developmental dental anomalies
• Patients undergoing or will start orthodontic treatment
• Patients with removable prosthesis
• Periapical Abscess or Fistula

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

Miswak

Experimental group

Description:

Miswak sticks used twice daily, every 12 hours, for three months.

Treatment:

Other: Miswak

Grape Seed Extract

Experimental group

Description:

Grape seed extract 6.5% mouthwash used twice daily, every 12 hours, for three months.

Treatment:

Other: Grape Seed Extract Mouthwash

Fluoride Mouthwash

Active Comparator group

Description:

0.05% fluoride mouthwash used twice daily, every 12 hours, for three months.

Treatment:

Other: fluoride