The Antipyretic Efficacy of Oral and Intravenous Paracetamol and Intramuscular Diclofenac in Patients Presenting With Fever.

Hamad Medical Corporation (HMC)

Status: Completed

Conditions: Fever; Reduction in Temperature

Treatments: Drug: Oral paracetamol; Drug: Intramuscular diclofenac; Drug: Intravenous paracetamol

Study type: Interventional

Funder types: Industry

Identifiers

NCT01891435

9070/09

Details and patient eligibility

About

A randomized clinical trial to check the antipyretic efficacy of oral and intravenous paracetamol and intramuscular diclofenac sodium in patients presenting with fever to emergency department.

Enrollment: 434 patients

Sex: All

Ages: 14 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults between the age of 14-75 years with an oral temperature of more than 38.5 C

Exclusion criteria

• History of allergy to any of the drugs in the study
• Had taken antipyretics within 8 hours
• Renal, hepatic or haematological disorders
• bronchial asthma, peptic ulcer disease, vomiting
• Pregnant or lactating women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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434 participants in 3 patient groups

oral paracetamol

Active Comparator group

Description:

patients in this arm will receive 1000mg of oral paracetamol

Treatment:

Drug: Oral paracetamol

Intravenous paracetamol

Active Comparator group

Description:

patients in this arm will receive 1000 mg of intravenous paracetamol

Treatment:

Drug: Intravenous paracetamol

Intramuscular Diclofenac

Active Comparator group

Description:

patients in this arm will receive 75 mg of intramuscular diclofenac sodium

Treatment:

Drug: Intramuscular diclofenac