The Application of Fibrin Glue in Ocular Surface Diseases

National Taiwan University

Status and phase: Withdrawn; Phase 1

Conditions: Pterygium; Corneal Ulcer

Treatments: Drug: tissue fibrin glue application (Tisseel)

Study type: Interventional

Funder types: Other

Identifiers

NCT00155402

940208

Details and patient eligibility

About

This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and muscle/clinical/filtering surgery.

Full description

This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries. The inclusion criteria are:

1. ocular surface disease which may need amniotic membrane transplantation (corneal pro epithelization, pterygium surgery, etc)
2. infectious or noninfectious corneal ulcer with perforation less than 3 mm
3. conjunctival transplantation/suture
4. corneal surgeries which can be treated by conventional suture technique or application with cyanoacrylic acid tissue glues.

Informed consents will be obtained from the patients before applications. After surgeries, topical steroids and antibiotics will be used, and therapeutic contact lens will be used. The patients will be followed up for at least three months.

Enrollment: 30 estimated patients

Sex: All

Ages: 3+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ocular surface diseases, which are expected to be treated by tissue fibrin glues

Exclusion criteria

• Pregnancy
• Children younger than 3 years old

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

1

Experimental group

Description:

Use of fibrin glue after corneal surgery or transplantation

Treatment:

Drug: tissue fibrin glue application (Tisseel)