The Application of Fibrin Glue in Ocular Surface Diseases

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National Taiwan University

Status and phase

Withdrawn
Phase 1

Conditions

Pterygium
Corneal Ulcer

Treatments

Drug: tissue fibrin glue application (Tisseel)

Study type

Interventional

Funder types

Other

Identifiers

NCT00155402
940208

Details and patient eligibility

About

This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and muscle/clinical/filtering surgery.

Full description

This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries. The inclusion criteria are: ocular surface disease which may need amniotic membrane transplantation (corneal pro epithelization, pterygium surgery, etc) infectious or noninfectious corneal ulcer with perforation less than 3 mm conjunctival transplantation/suture corneal surgeries which can be treated by conventional suture technique or application with cyanoacrylic acid tissue glues. Informed consents will be obtained from the patients before applications. After surgeries, topical steroids and antibiotics will be used, and therapeutic contact lens will be used. The patients will be followed up for at least three months.

Enrollment

30 estimated patients

Sex

All

Ages

3+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Ocular surface diseases, which are expected to be treated by tissue fibrin glues

Exclusion criteria

  • Pregnancy
  • Children younger than 3 years old

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

30 participants in 1 patient group

1
Experimental group
Description:
Use of fibrin glue after corneal surgery or transplantation
Treatment:
Drug: tissue fibrin glue application (Tisseel)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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