The Association Between Advancing Age and Mortality at 30 Days in Patients With Bacteremia E. Coli Beta-lactamase Phenotype Extended Spectrum RC15_0421 (MoBaCo)

Nantes University Hospital (NUH)

Status: Completed

Conditions: Beta-lactamase Extended Spectrum, E. Coli, Elderly, Mortality, Risk Factor

Study type: Observational

Funder types: Other

Identifiers

NCT02847065

RC15_0421

Details and patient eligibility

About

In the US and Europe, bacteremia are ranked the 7th leading cause of death from all causes. E. coli is one of the main microorganism involved, responsible for 30% to 45% of bacteremia. In Europe, bacteremia E. coli, including BLSE phenotype, have a strong impact on public health, causing increased mortality, particularly in the elderly, and an increase in the average hospital stay. However, few studies have specifically concerned with the criteria associated with mortality of elderly patients with BLSE E. coli bacteremia. Finally, improving epidemiological knowledge of the elderly patients with bacteremia due to BLSE E. coli has importance in terms of public health and is a prerequisite to the development of preventive strategies and to improve the short-term prognosis.

Enrollment: 144 patients

Sex: All

Ages: 65 to 105 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients with positive blood culture E. coli BLSE will be included in the study. Bacteremia E. coli BLSE will be defined as the identification of one or more blood cultures positive for E. coli BLSE in patients with clinical criteria of systemic inflammatory response, at least two of the following 4 criteria:

  • temperature> 38 ° C or < 36 ° C;
  • heart rate> 90 beat / min;
  • respiratory rate > 20 c / min or PaCO2 < 32 mmHg;
  • WBC > 12,000 / microL or < 4000 / microL or 10% immature forms

Exclusion criteria

• For each patient included, only the first episode of bacteremia will be included in the study