The Association Between Blood Eosinophilsp in Thai COPD Patients: A Prospective Study

Prince of Songkla University

Status: Completed

Conditions: Copd

Treatments: Other: observatory

Study type: Observational

Funder types: Other

Identifiers

NCT04123028

60-319-14-3

Details and patient eligibility

About

The association of blood eosinophil as a biomarker for eosinophilic Thai COPD patients, such as COPD exacerbation, hospital admission, lung functions and mortlity.

Full description

The prospective one year study in Thai COPD patients for the clinical outcomes of COPD compare between eosinophilic and non-eosinophilic which determine by blood eosinophil counts equal or more than 300 cells/microliters. The primary outcomes was COPD exacerbation, the secondary outcomes were lung function, dyspnea and quality of life.

Enrollment: 145 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of COPD by GOLD criteria

Exclusion criteria

1. high blood eosinophil from known causes such as systemic corticosteroid use, malignancy, parasitic infection
2. Patients who had previous acute exacerbation within 30-day before study entry
3. Patients who had previous systemic corticosteroids used within 30-day before study entry

Trial design

145 participants in 2 patient groups

eosinophilic COPD patient

Description:

COPD patient with blood eosinophil equal or \> 300 cells/µL

Treatment:

Other: observatory

non-eosinophilic COPD patient

Description:

COPD patient with blood eosinophil \< 300 cells/µL

Treatment:

Other: observatory