The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma

University Medical Centre Ljubljana

Status: Not yet enrolling

Conditions: Colorectal Carcinoma; Infertility; Bowel Endometriosis; Endometriosis Pelvic; Deep Endometriosis; Colon Resection; Endometriosis; Genetic Change; Endometriosis Rectum; Carcinogenesis

Study type: Observational

Funder types: Other

Identifiers

NCT07386431

20250256

Details and patient eligibility

About

The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma. The study will include patients for whom surgical treatment of bowel endometriosis is clinically indicated.

This research would represent a significant advancement in evaluating the necessity of surgical intervention in asymptomatic patients or those with mild symptoms. Furthermore, it would provide a broader insight into the systemic impact of endometriosis on other organ systems, ultimately improving risk assessment and preventive measures.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Female patients aged 18 and over, treated at the Department of Reproduction for diagnosed deep endometriosis, including bowel endometriosis, for whom surgical treatment is indicated.

Exclusion criteria

• Patients with known inflammatory bowel disease (IBD), patients with a personal history of gynecological or gastrointestinal malignancy