The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings

Chinese Academy of Medical Sciences & Peking Union Medical College

Status and phase: Unknown; Phase 4

Conditions: Syphilis

Treatments: Drug: Benzathine Penicillin G

Study type: Interventional

Funder types: Other

Identifiers

NCT02871505

PUMCH-2016079

Details and patient eligibility

About

The investigators compare the treatment results and clicical presentations of different Molecular subtyping of Treponema pallidum

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

1. Persons with confirmed early symptomatic syphilis (primary or secondary) or high-titer latent syphilis

Exclusion Criteria:

1. Pregnant woman
2. Known allergy to penicillin
3. RPR titers were found to be 1:8 or less

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 2 patient groups

Molecular subtyping (14d/f) of Treponema pallidum

Experimental group

Description:

Benzathine Penicillin G treatment

Treatment:

Drug: Benzathine Penicillin G

Molecular subtyping (others) of Treponema pallidum

Experimental group

Description:

Benzathine Penicillin G treatment

Treatment:

Drug: Benzathine Penicillin G