The Association Between Monocyte Subsets and Coronary Collateral Development in Diabetes Mellitus

Samsun Education and Research Hospital

Status: Completed

Conditions: Coronary Artery Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01671306

1037

Samsun EAH (Other Identifier)

Details and patient eligibility

About

Monocyte heterogeneity in peripheral blood seems to be important in coronary collateral development in non-diabetic patients with stable coronary artery disease. Our aim in this study is to find out any possible relationship between the levels of circulating monocyte subsets and coronary collateral development in type 2 diabetic patients.

Full description

83 diabetic patients with severe coronary artery disease were enrolled in the study. These patients were investigated according to their collateral development. Monocytes and their subtypes, namely CD14++CD16- and CD14+CD16+ cells were compared in 2 groups

Enrollment: 83 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• presence of > 95% stenosis of at least one major coronary artery in their first coronary angiogram.

Exclusion criteria

• Patients experiencing acute coronary syndrome either with or without ST elevation in the last one month
• Evidence of ongoing infection and inflammation, known malignancy and chronic kidney disease

Trial design

83 participants in 2 patient groups

Collateral, coronary disease

Description:

Patients are grouped into 2: Good and poor collateral development

collateral

Description:

Patients are grouped into 2: Good and poor collateral development