The Association Between Periodontal Disease and Malnutrition in a Group of Elderly People in Thailand.

Mahidol University

Status: Completed

Conditions: Malnutrition; Periodontal Diseases

Treatments: Behavioral: the association between periodontitis and malnutrition status

Study type: Interventional

Funder types: Other

Identifiers

NCT05129826

MU-DT/PY-IRB 2019/051.1408

Details and patient eligibility

About

This study will be determine the association between periodontitis and malnutrition status in older adult.

Full description

Ageing may accompany with an accumulation of diseases and impairments cause by physiological, socioeconomic and psychological changes. The older adults are more prone to nutritional deficiencies due to combination of factors such as ageing, excessive polypharmacy, general health decline, poor socioeconomic status, cognitive decline, poor appetite, impaired efficacy of swallowing and limit eating ability.

Periodontitis is a multifactorial disease predominantly a bacterial infection involving the dental biofilm or dental plaque. Periodontitis increases in extent and severity across a large proportion of the human population with ageing. The effects of ageing on the immune system include distinct alterations in both innate and adaptive immune-cell function and effector biomolecules, resulting in processes reflecting immunosenescence, immunoactivation and inflammaging. Moreover, genetic contribution alters immunity and inflammation that play a role in the dysregulation of host responses in ageing. The combination of chronic antigenic burden and uncontrolled inflammatory response can enhance immunosenescence and ageing-associated disease. Periodontitis also has an effect on food intake, nutritional status and quality of life in older adults.

However the relationship between chronic periodontitis and malnutrition in older adult is not clear and needs further study. In this study will be determine the association between periodontitis and malnutrition status in older adult.

Enrollment: 78 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Subjects who has aged ≥ 60 years old.
2. Subjects who not receive periodontal treatment within the previous 6 months.
3. Subjects who are able to read Thai and express verbal communication.
4. Subjects who are functional independent older adults (get ≥ 12 points from Barthel Index for Activities of Daily Living) [50, 51].
5. Subjects who are cognitive functional independent older adults (get > 23 points from Thai Mental State Examination) [52].

Exclusion criteria

1. Subjects with completely edentulous area.
2. Subjects who require antibiotic prophylaxis for dental examination

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

78 participants in 1 patient group

older adult

Experimental group

Description:

Subjects who has aged ≥ 60 years old.

Treatment:

Behavioral: the association between periodontitis and malnutrition status