The Association Between SIRI and POD in Older Patients

Naval Military Medical University

Status: Completed

Conditions: Surgery; Elderly; Postoperative Delirium

Study type: Observational

Funder types: Other

Identifiers

NCT05797194

POD-SIRI

Details and patient eligibility

About

Postoperative delirium (POD) remains one of most common complication in elderly patients receiving surgery, which is characterized by acute and fluctuating change in the level of cognition and consciousness. Previous studies have shown that surgery and anesthesia-induced acute peripheral inflammation and neuroinflammation may lead to delirium after surgery. Systemic Inflammation Response Index (SIRI) is a more easily accessible and comprehensive inflammation marker derived from monocyte, neutrophil, and lymphocyte count, which has been investigated to assess the prognosis of cancer and infectious diseases. However, the relationship between SIRI and POD has yet to be investigated.

Enrollment: 116 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospital stay of at least 3 days
• More than or equal to 65 years old
• Elementary education or above
• Able to communicate
• American Society of Anesthesiologists (ASA) physical status I-III
• Mini-mental State Examination (MMSE) scores ≥ 22 points

Exclusion criteria

• Preoperative delirium
• Severe mental diseases
• Autoimmune-illness, chronic infectious diseases, nervous system diseases and malignancies

Trial design

116 participants in 2 patient groups

POD group

Description:

Patients were considered to surfer from postoperative delirium by a positive Confusion Assessment Method (CAM) questionnaire after surgery.

No-POD group

Description:

Patients did not surfer from postoperative delirium by a positive CAM questionnaire after surgery.