The Association Between the Intraoperative Blood Pressure Changes and Whole Exome Genome

National Taiwan University

Status: Not yet enrolling

Conditions: the Association Between the Arterial Stiffness, Intraoperative Blood Pressure Changes and Genetic Effect

Treatments: Other: this study did not involve interventions; it only observational study

Study type: Observational

Funder types: Other

Identifiers

NCT05730140

202209125RINC

Details and patient eligibility

About

The intraoperative blood pressure changes have been important for postoperative morbidity and mortality. However, some patients did not occur intraoperative hypotension but some patients would have severe intraoperative hypotension. It may be associated with genome related. In this hypothesis, we aim to elucidate the association between the whole exome genome and intraoperaive blood pressure changes.

Full description

We aim to elucidate the association between the whole exome genome and intraoperative blood pressure changes.

We will enroll patients older than 20 years old and undergo elective general anesthesia.

Before anesthesia, we will obtain blood sample for whole exome genome test and give arterial line for intraoperative monitor.

After completing surgery, we will follow the patients' all postoperative major organ function.

We hope this study to be able to give us the more information about the specific genetic effect on the arterial stiffness and intraoperative blood pressure changes.

Enrollment: 30 estimated patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective general surgery

Exclusion criteria

• coagulopathy

Trial design

30 participants in 1 patient group

patients undergoing general anesthesia

Description:

patients undergoing general anesthesia

Treatment:

Other: this study did not involve interventions; it only observational study