The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders (SA1PLG)

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Status: Completed

Conditions: Pulmonary Disease, Chronic Obstructive; Generalized Chronic Periodontitis

Treatments: Genetic: SERPINA1 gene

Study type: Observational

Funder types: Other

Identifiers

NCT02498938

D149206031

Details and patient eligibility

About

Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.

Full description

periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase

COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs.

SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums.

Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.

Enrollment: 60 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male and female patients aged between 30-70yrs diagnosed with COPD and chronic periodontitis who are willing to participate in the study.

Exclusion criteria

• Pateints with other systemic disorders
• patients not willing to participate in the study

Trial design

60 participants in 1 patient group

SERPINA1 gene in COPD and periodontitis

Description:

patients aged between 30-70 yrs with COPD (satisfying Gold's criteria) and chronic periodontitis (\>4mm pocket probing depth)

Treatment:

Genetic: SERPINA1 gene