The Attenuating Effect of Soluble Fiber Consumption on Postprandial Glycemia in Humans

Purdue University

Status: Completed

Conditions: Postprandial Hyperglycemia; Type2 Diabetes; Blood Sugar; High

Treatments: Other: Control; Other: Resistant Starch Type 4; Other: Isomaltodextrin Low Dose; Other: GPC partially digestible maltodextrin; Other: Isomaltodextrin High Dose

Study type: Interventional

Funder types: Other

Identifiers

NCT05349916

IRB-2021-122

Details and patient eligibility

About

The main objective of the current study is to investigate whether consumption of soluble fibers (isomaltodextrin [IMD], partially digestible maltodextrin) and RS4 starch will lower postprandial glycemia as well as postprandial insulin in human subjects with relatively high fasting blood glucose, when consumed with a specific amount of digestible carbohydrate (rice porridge). The primary outcome of the study is the effect of fibers on postprandial blood glucose, whereas the secondary outcome will be its effect on postprandial blood insulin.

Enrollment: 24 patients

Sex: All

Ages: 22 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index (18.5 kg/m² ≤ BMI ≤ 29.9 kg/m²)
• No history of abnormal glucose metabolism
• No ongoing use of drugs affecting blood glucose levels
• Fasting blood glucose between 90-110 mg/dL
• Low dietary fiber intake (less than 15 g per day)

Exclusion criteria

• Diabetic individuals
• Individuals with history of gastrointestinal disease
• Pregnant or nursing women

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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24 participants in 5 patient groups

Control

Experimental group

Treatment:

Other: Control

Isomaltodextrin Low Dose

Experimental group

Treatment:

Other: Isomaltodextrin Low Dose

Isomaltodextrin High Dose

Experimental group

Treatment:

Other: Isomaltodextrin High Dose

GPC partially digestible maltodextrin

Experimental group

Treatment:

Other: GPC partially digestible maltodextrin

Resistant Starch Type 4

Experimental group

Treatment:

Other: Resistant Starch Type 4