The Balance Control Mechanism of DPN Patients

Geheng Yuan

Status: Unknown

Conditions: Diabetic Neuropathy

Study type: Observational

Funder types: Other

Identifiers

NCT02606747

11372013

Details and patient eligibility

About

This study will evaluate the balance ability of DPN (diabetic peripheral neuropathy)patients, which will help us to understand the relationship between peripheral and central nervous system, in order to early diagnosis and prevent the fall in DPN patients.

Full description

DPN is one of the most common complications of diabetes. The clinical manifestation of DPN contains sensory reduction, pain, muscle wastage and so on. Sensory and motor nervous are one of the most important factors in balance control, the reduction of balance ability will result in high risk of fall.

Most studies about DPN are focus on peripheral nervous, however, the central nervous system may also be involved in DPN patients. In this study, force platform, proprioception test and fMRI will be used to evaluate balance ability, proprioception and the brain function information of DPN patients, which will help to understand the relationship between peripheral and central nervous system.

Enrollment: 200 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diabetics
• normal cognitive ability
• walk normally
• normal vision

Exclusion criteria

• other nervous system disease, foot ulcer

Trial design

200 participants in 2 patient groups

Diabetes mellitus with DPN

Description:

Aged from 40 to 80. Normal cognitive ability. Right handed. Able to walk without any other kinds of central nervous system disorder. Confirmed diabetes with DPN.

Diabetes mellitus without DPN

Description:

Aged from 40 to 80. Normal cognitive ability. Right handed. Able to walk without any other kinds of central nervous system disorder. Confirmed diabetes without DPN.