The BeLimumab Antiphospholipid Syndrome Trial (BLAST)

University of Turin

Status and phase

Enrolling

Phase 3

Phase 2

Conditions

Antiphospholipid Syndrome

Treatments

Drug: Belimumab

Study type

Interventional

Funder types

Other

Identifiers

NCT05020782

APSGB01

Details and patient eligibility

About

AIM: The primary objective of the BeLimumab Antiphospholipid Syndrome Trial (BLAST) is to evaluate the safety and tolerability of belimumab for up to 24 months in patients with persistent aPL positivity and clinical features attributable to aPL that are resistant to warfarin and/or heparin.

Enrollment

15 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

• Positive aPL profile defined as: Positive lupus anticoagulant test as defined by the International Society on Thrombosis and Haemostasis, on two or more occasions, at least 12 weeks apart and/or Positive anticardiolipin antibody (aCL) immunoglobulin G(Ig)G/M/A isotype, present in > 40U, on two or more occasions, at least 12 weeks apart and/or Positive anti-β2-glycoprotein-I (aβ2GPI) IgG/M/A isotype, present in > 40U, on two or more occasions, at least 12 weeks apart

AND

• Clinical features attributable to aPL that are resistant to warfarin and/or heparin:

Recurrent thrombosis despite ongoing anticoagulation and/or
Persistent thrombocytopenia and/or
Persistent autoimmune hemolytic anemia and/or
Cardiac valve disease and/or
Chronic skin ulcers and/or
Renal thrombotic microangiopathy and/or
Cognitive dysfunction with/without white matter changes

Exclusion criteria

>=4/11 American College of Rheumatology Classification Criteria for SLE
Acute thrombosis (arterial or venous acute thrombosis diagnosis less than 30 days before study screening)
History of stroke Acute or chronic pancreatitis
Pregnancy
Have a history of malignant neoplasm within the last 5 years except basal cell or squamous cell carcinoma of the skin treated with local resection only or carcinoma in situ of the uterine cervix treated locally and with no evidence of metastatic disease for 3 years
Have evidence of serious suicide risk including any history of suicidal behaviour in the last 6 months and/or any suicidal ideation in the last 2 months or who in the investigator's judgment, poses a significant suicide risk
Have a history of a primary immunodeficiency
Have a significant IgG deficiency (IgG level < 400 mg/dL)
Have an IgA deficiency (IgA level < 10 mg/dL)
Known active bacterial, viral fungal mycobacterial, or other infection
Infection history:
Currently on any suppressive therapy for a chronic infection (such as tuberculosis, pneumocystis, cytomegalovirus, herpes simplex virus, herpes zoster and atypical mycobacteria)
Hospitalization for treatment of infection within 60 days of Day 0.
Use of parenteral (IV or IM) antibiotics (anti-bacterial, antiviral, anti-fungal, or antiparasitic agents) within 60 days of Day 0
Have current drug or alcohol abuse or dependence, or a history of drug or alcohol abuse or dependence within 365 days prior to Day 0
Have a historically positive HIV test or test positive at screening for HIV
Hepatitis status:
Serologic evidence of current or past Hepatitis B (HB) infection based on the results of testing for HBsAg and HBcAb as follows:
Patients positive for HBsAg or HBcAb are excluded
Positive test for Hepatitis C antibody
Have a history of an anaphylactic reaction to parenteral administration of contrast agents, human or murine proteins or monoclonal antibodies
Have any other clinically significant abnormal laboratory value in the opinion of the investigator
If Women of Child-Bearing Potential (WCBP) are included, please see special instructions below.
Have any intercurrent significant medical or psychiatric illness that the investigator considers would make the candidate unsuitable for the study