The Benefit of 5% IVIG for Patients With Primary Immunodeficiency Disorders Who Experience Adverse Events on 10% IVIG Preparations

I

IMMUNOe Research Centers

Status

Completed

Conditions

Primary Immunodeficiency

Study type

Observational

Funder types

Industry

Identifiers

NCT03339778
IIS201401-PID

Details and patient eligibility

About

Patients with primary immunodeficiency disorders (PID) on intravenous immunoglobulin (IVIG) treatment may experience adverse events (AEs). Patients who experience AEs on any 10% IVIG solution will be changed to octagam 5% for six infusions to evaluate the potential benefit for reduction of AEs on a lower concentration IVIG product.

Full description

Patients with PID require life long immunoglobulin (Ig) replacement therapy with IVIG being the most common form. As more 10% IVIG products are FDA approved, the older and well characterized 5% IVIG products are becoming less used. Currently, the standard of care for patients who experience AEs on IVIG is to move to a subcutaneous (SCIG) delivery and product. This study will evaluate the AEs on a 10% product and octagam 5%. The study will enroll 15 patients after an AE on any 10% product who will then be infused with octagam 5% for six infusions. AEs will be documented and compared to the 10% product along with changes in biomarkers. The study data may document another therapeutic option for patients who experience AEs - SCIG and octagam 5%.

Enrollment

15 patients

Sex

All

Ages

10 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Participants, or legal guardians with assent by underage children, will sign informed consent/assent and are willing to comply with all aspects of the study
  • Diagnosis of CVID according IUIS Expert Committee
  • Participants on a 10% product who experience AEs
  • Ages between 10 and 75 years of age
  • Participants on 10% IVIG therapy every 21±3 days or 28±3 days between 300 - 800 mg/Kg body weight

Exclusion criteria

  • Acute infection requiring antibiotic therapy within 7 days prior to visit 1
  • Presence of any condition that is likely to interfere with the evaluation of the study medication or satisfactory conduct of the trial
  • History of anaphylactic or severe systemic reactions to human immunoglobulin
  • IgA deficient patients with antibodies against IgA and a history of hypersensitivity
  • Females who are pregnant or lactating

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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