The Benefit of Autologous Blood Transfusion in Total Hip Arthroplasty

Clinical Hospital Centre Zagreb

Status: Completed

Conditions: Transfusion; Hip Arthroplasty

Treatments: Procedure: Without preoperative blood donation; Procedure: Preoperative autologous blood donation, 14 days before surgery; Procedure: Preoperative autologous blood donation, 72 hours before surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT04304287

Orthopedia/autotransfusion

Details and patient eligibility

About

The investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized.

Full description

Total hip arthroplasty is procedure followed with large perioperative and postoperative blood loss. In order to avoid the application of large amounts of allogeneic blood, preoperative autologous blood donation as a tipe of autologous transfusion have been developed.

In this study, the investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized.

Participants were divided into three groups: the first group donated one dose of autologous blood 14 days preoperatively, the second group donated one dose of autologous blood 72 hours preoperatively and a third group was not donated autologous blood.

The blood parameters, hemodynamic stability, bleeding, the need for application of autologous or homologous blood and length of hospital stay were compared.

Enrollment: 75 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• subject older than 18 years
• subject has primary coxarthrosis
• subject has indication for total hip replacement

Exclusion criteria

• subject has secondary coxarthrosis
• subject has need for revision endoprosthesis
• history of autoimmune, malignancy or coagulation disorder
• history of myocardial infarct or cerebrovascular insult in last 6 months
• history of angina pectoris and unregulated hypertension
• history of renal or liver failure

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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75 participants in 3 patient groups

Experimental

Experimental group

Description:

Preoperative blood donations 14 day before total hip replacement procedure Donation of one dose of autologous blood 14 day before total hip replacement procedure

Treatment:

Procedure: Preoperative autologous blood donation, 14 days before surgery

Active comparator

Active Comparator group

Description:

Preoperative blood donation 72 hours before total hip replacement procedure Donation of one dose of autologous blood 72 hours before total hip replacement procedure

Treatment:

Procedure: Preoperative autologous blood donation, 72 hours before surgery

Other

Other group

Description:

Without preoperative blood donation

Treatment:

Procedure: Without preoperative blood donation