The Benefits of Early Initiation of Continual Renal Replacement Therapy in Patients With Severe Sepsis

Radovan Uvizl

Status: Unknown

Conditions: Severe Sepsis

Treatments: Procedure: renal replacement therapy

Study type: Observational

Funder types: Other

Identifiers

NCT03141112

ECRRT 51/16

Details and patient eligibility

About

The study will evaluate the benefit of early initiation of CRRT in the initial phase of severe sepsis in patients admitted to the ICU. Primary evaluated end-point is 28-day mortality. Secondarily evaluated end-point is length of ICU-stay, length of stay in hospital, duration of mechanical ventilation. There are two groups. One group of participants with early CRRT initiation and another group with late CRRT initiation. Reference group no CRRT.

Full description

The aim is to determine the optimal timing of initiation of CRRT with respect to the degree and duration of acute kidney injury (AKI) in ICU patients. The CRRT parameters and the duration of therapy will be monitored, depending on initial biochemical and clinical values of the patient. Part of the study is the follow-up of patients with a 3-month delay.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• reaching criteria of severe sepsis, ICU admission

Exclusion criteria

• pregnant women, younger than 18 years, reaching contraindications for initiation of renal replacement therapy

Trial design

200 participants in 2 patient groups

early CRRT initiation

Description:

Patients in ICU with severe sepsis, both gender, adult, over 18 years od age. Initiation of renal replacement therapy up to 48 hours after reaching criteria of severe sepsis.

Treatment:

Procedure: renal replacement therapy

late CRRT initiation

Description:

Patients in ICU with severe sepsis, both gender, adult, over 18 years od age. Initiation of renal replacement therapy after 48 hours after reaching criteria of severe sepsis.

Treatment:

Procedure: renal replacement therapy