The Bioavailability of Polyacetylenes From Carrots Study

N

Newcastle-upon-Tyne Hospitals NHS Trust

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: Carrot

Study type

Interventional

Funder types

Other

Identifiers

NCT02696473
Carrot_01

Details and patient eligibility

About

Polyacetylenes, compounds found naturally in carrots, have shown promising anti-cancer and anti-inflammatory actions in vitro but have not been tested in vivo. To determine whether the polyacetylenes could have an effect in vivo, this study aims to determine whether they are detectible in human biofluids after the consumption of a portion of carrots and whether a difference is seen between a large and small portion.

Full description

Volunteers will collect urine samples 24 hours prior to the 'test' day and a stool sample either the night before or the morning of the test session. They will have fasted blood taken before eating a portion of carrots with bread and butter. Further blood samples will be taken at 0.5, 1, 2, 3, 4, 6, 8 and 24 hours. All urine and all stool samples (after 4 hours) will be collected up to 48 hours after the carrot dose. They volunteers will attend two test sessions and will be randomised to receive high and low doses of carrot. At least a week will separate testing sessions.

Enrollment

6 patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy adults, BMI between 18.5 and 30

Exclusion criteria

  • Metabolic or gastrointestinal conditions, allergies to carrot or bread, taking any medication that affects metabolism or digestion, smokers

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

6 participants in 2 patient groups

High Carrot Dose
Experimental group
Description:
The volunteer will eat 250g carrot for breakfast with 2 slices of bread and 10g butter
Treatment:
Dietary Supplement: Carrot
Low Carrot Dose
Experimental group
Description:
The volunteer will eat 100g of carrot for breakfast with 2 slices of bread and 10g butter
Treatment:
Dietary Supplement: Carrot

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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