The Biomarkers Of RIsk of Colorectal Cancer (BORICC) Follow-Up (BFU) Study

Newcastle University

Status: Completed

Conditions: Colorectal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT04005742

207081

Details and patient eligibility

About

Worldwide, colorectal cancer is the 3rd most common cancer; risk increases with age and is modified by lifestyle factors notably diet, physical activity and obesity. The BORICC Follow-Up (BFU) Study is a 12+ year follow-up of participants recruited to the Biomarkers of Risk of Colon Cancer (BORICC) Study. This longitudinal study will investigate associations between ageing and lifestyle factors and a panel of molecular biomarkers linked with colorectal cancer risk.

Full description

The BORICC Follow-Up (BFU) Study builds on the findings from the BORICC Study where the investigators observed associations between age and nutritional factors, including selenium and folate, and biomarkers of colorectal health.

The BFU Study will investigate the relationships between ageing (12+ years) and such biomarkers longitudinally. It is anticipated that the project will produce novel data on (i) changes in biomarkers of colorectal cancer risk with age and (ii) the effects of obesity and lifestyle factors on biomarkers of colorectal cancer risk. These biomarkers include differentially expressed proteins, DNA methylation markers and inflammation markers.

Enrollment: 47 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Took part in the BORICC Study at baseline (recruited 2005/6)

Exclusion criteria

• Unable to travel to the hospital to attend study visit
• Unable to provide informed written consent

Trial design

47 participants in 2 patient groups

Healthy

Description:

Participants recruited to the healthy arm of the BORICC Study (BORICC1) at baseline.

Polyp

Description:

Participants recruited to the polyp arm of the BORICC Study (BORICC2) at baseline, with a prior history of polyps.