The Biopsychosocial Model to Identify Risk Factors for Chronic Post-traumatic Pain in ICU Patients (TRAUMA-PAIN)

University Hospital Center (CHU)

Status: Enrolling

Conditions: Post Traumatic Chronic Pain

Treatments: Other: biological collection of residual peripheral venous blood samples; Other: collection of data from medical records

Study type: Observational

Funder types: Other

Identifiers

NCT07491354

2025-07-324

Details and patient eligibility

About

This study aims to assess multidimensional risk factors for chronic post-traumatic pain in polytrauma patients. The purpose is to better understand pain chronification mechanisms by quantifying the interaction between clinical, biological, therapeutic, and psychosocial factors during hospitalization, with the ultimate goal of developing a convergent model to predict patients at risk before hospital discharge.

Full description

According to the International Classification of Diseases 11th (ICD-11) classification, chronic post-traumatic pain is defined as pain persisting for more than 3 months following tissue injury. Given its physical, psychological, and social consequences, chronic pain represents a major source of disability, functional limitation, and impaired quality of life. Chronic pain frequently develops after accidental trauma, particularly in patients sustaining musculoskeletal injuries such as fractures.

The primary objective of this study is to identify early risk factors associated with chronic post-traumatic pain. In this study, patients undergo a comprehensive multidimensional evaluation throughout hospitalization. Trauma-related characteristics, including injury mechanism, severity, and lesion location, as well as therapeutic management, are systematically documented. Psychosocial factors and post-traumatic symptoms are assessed during hospitalization and at 3- and 6-month follow-up visits.

In addition to clinical and psychosocial assessments, biological samples are collected from hospital admission until discharge. This biological component focuses on brain-derived neurotrophic factor (BDNF). BDNF, initially described for its role in synaptic plasticity, has been increasingly implicated in central sensitization processes involved in pain chronification. By integrating clinical, biological, therapeutic, and psychosocial data, this study aims to characterize mechanisms associated with chronic post-traumatic pain and to develop a convergent predictive model to identify patients at high risk prior to hospital discharge.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients aged 18 years or older
• Patients with an Abbreviated Injury Scale (AIS) score greater than 1
• Patients presenting with at least one documented fracture

Exclusion criteria

• Patients with an isolated fracture of the carpal bones
• Patients with isolated traumatic brain injury
• Patients with isolated minor facial trauma
• Patients with isolated digestive trauma

Trial design

400 participants in 1 patient group

TRAUMApain ICU Cohort

Description:

This cohort includes adult patients admitted to the intensive care unit (ICU) for traumatic injuries. Eligible patients are aged 18 years or older, with an Abbreviated Injury Scale (AIS) score greater than 1, and have at least one documented fracture.

Treatment:

Other: collection of data from medical records

Other: biological collection of residual peripheral venous blood samples