The Bipolar Illness Onset Study (the BIO Study)

Mental Health Services in the Capital Region, Denmark

Status: Active, not recruiting

Conditions: Bipolar Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT02888262

Psychiatric Center Copenhagen

Details and patient eligibility

About

This longitudinal study aims to identify 1) a composite blood-based biomarker, 2) a composite electronic Smartphone-based biomarker and 3) a neurocognitive signature for bipolar disorder

Full description

The study will include 300 patients with newly diagnosed/first episode bipolar disorder, 200 healthy siblings or child family members and 100 healthy individuals without a family history of affective disorder. All individuals will be investigated with repeated blood tests, Smartphone recordings, neuropsychological tests and brain imaging during a five to ten year study period.

Enrollment: 700 patients

Sex: All

Ages: 16+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Newly diagnosed/first episode bipolar patients,
2. First-generation relatives (siblings and children aged 15 to 40 years) to the recruited newly diagnosed/first episode bipolar patients.
3. Age- and gender matched sample of healthy individuals without a first-generation family history of effective disorders

Exclusion criteria

1. Significant physical disorders
2. Schizophrenia or related disorders

Trial design

700 participants in 3 patient groups

Patients with bipolar disorder

Description:

Patients with newly diagnosed bipolar disorder

Healthy first generation relatives

Description:

Healthy first generation relatives to the included patients

Healthy individuals

Description:

Healthy individuals without a family history of psychiatric disorders