The Born in Guangzhou Cohort Study (BIGCS)

Guangzhou Women and Children's Medical Center

Status: Enrolling

Conditions: Host and Microbiome; Immune Development; Childhood Obesity; Pregnancy Outcomes; Neurodevelopment; Intrauterine Hyperglycemia

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02526901

2011Y2-00025

201041-E00741 (Other Grant/Funding Number)

2012J5100038 (Other Grant/Funding Number)

201508030037 (Other Grant/Funding Number)

Details and patient eligibility

About

The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China. Data are collected regarding environmental, occupational and lifestyle exposures as well as health outcomes in later life. Biological samples including blood and tissue samples are also collected from the participants.

Full description

Over the past three decades, China is undergoing rapidly economic development. At the same time, the Western diet and urban lifestyle has been more common than before, which may lead to an increase of incidence of non-communicable chronic diseases, such as diabetes and malignancies. Notably, the current generation of Chinese adults, particularly those in their middle age or older, were born in an era where hardship and rationing was the norm and witnessed a social and epidemiological transition that might have a profound effect on their present health. In contrast, the younger generation is raised in relative material abundance, under the influence of traditional Chinese values such as a strong family orientation and an emphasis on academic success. A birth cohort with would provide an opportunity to examine the short- and long-term effects of exposure in early life on health consequences in this younger generation, in the context of rapid development in China.

Enrollment: 30,000 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Pregnant women with <20 weeks of gestation
• Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
• Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years

Trial design

30,000 participants in 1 patient group

No treatment

Treatment:

Other: No intervention