The Cardioprotective Effect of Intralipid in Decreasing the Ischemic Insults During Off-pump Coronary Artery Revascularization

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Anesthesia

Treatments: Drug: Intralipid; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT04806425

FMASU R 126/2020

Details and patient eligibility

About

the aim of the study is to assess the effect of intralipid as regard efficiency in decreasing myocardial ischemia , given during preconditioning in off pump coronary artery revascularization

Enrollment: 46 patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients between 40 to 75 undergoing off bump CABG surgery

Exclusion criteria

• emergency surgery
• Ejection fraction less than 50%
• redo procedures
• history of allergy to peanuts

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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46 participants in 2 patient groups, including a placebo group

IL group

Active Comparator group

Description:

receive 1.5 ml /kg intralipid 20% through Central venous line after sternotomy over 1 hour

Treatment:

Drug: Intralipid

NS group

Placebo Comparator group

Description:

recieve 1.5 ml /kg normal saline 0.9% through central venous line after sternotomy over 1 hour

Treatment:

Drug: Placebo