The Cardiovascular Benefits of Reducing Personal Exposure to Air Pollution

University of Edinburgh

Status: Completed

Conditions: Heart Rate Variability; Blood Pressure

Treatments: Other: No Face mask; Device: Face mask (Dust Respirator)

Study type: Interventional

Funder types: Other

Identifiers

NCT00809432

167/2008/Pilot

Details and patient eligibility

About

Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia. The study objectives were to assess the potential cardiovascular benefits of reducing personal particulate air pollution exposure by wearing a facemask in healthy volunteers.

Enrollment: 15 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

• Current smokers
• Significant occupational exposure to air pollution
• Regular medication use (except oral contraceptive pill)
• Intercurrent illness

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

Visit 1

Experimental group

Description:

2 hour city centre kerbside walk in Beijing China

Treatment:

Other: No Face mask

Visit 2

Experimental group

Description:

2 hour city centre kerbside walk in Beijing China

Treatment:

Device: Face mask (Dust Respirator)