The Cartagena Cohort Study (CaReS)

Universidad de Cartagena

Status: Invitation-only

Conditions: Cardiovascular Diseases; COPD; Atherosclerosis; Lung Function Decreased

Treatments: Other: Diet; Behavioral: Physical activity; Genetic: Genetic risk variants; Other: Socio-economic conditions

Study type: Observational

Funder types: Other

Identifiers

NCT05339048

CCS

Details and patient eligibility

About

Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not fully understood. The aim of CaReS is to elucidate the shared pathophysiology of impaired lung function and cardiovascular risk, and to investigate the risk factors associated with them.

The CaReS Cohort Study includes adults (18-80 years old) from Cartagena de Indias, a tropical city on Colombian Caribbean Coast, where recent population admixture settled a three-hybrid genetic structure (European, African and Ameridian ancestry). At baseline, the cohort will generate extensive data on -omics (e.g., genomics, transcriptomics, metabolomics, and epigenomics), socio-economic wellbeing, lifestyle, medical history, cardiometabolic, inflammatory and liver function markers, as well as objective measures of ventilatory and cardiovascular performance.

The cohort will collect data every three years, for a total period of ten years. Prospective risk of cardiovascular disease and chronic obstructive pulmonary disease (COPD) will be investigated, and their risk factors. Throughout the study period, changes in prevalence, and interactions of various risk factors with these changes will also be ascertained.

A predictive risk score for cardiovascular and chronic respiratory disability will be built, using cross-sectional and longitudinal data.

Enrollment: 619 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults
• Native from Colombian Caribbean Coast

Exclusion criteria

• Pregnant women
• Walking physical disability
• Cognitive disability
• Patients under treatment for any type of cancer
• Clinical record of primary chronic endocrine disease
• Clinical record of major respiratory tract surgery

Trial design

619 participants in 1 patient group

General group

Description:

18-80 years old adults from the Colombian Caribbean Coast.

Treatment:

Other: Socio-economic conditions

Behavioral: Physical activity

Genetic: Genetic risk variants

Other: Diet