The Causative Insects in Severe Insect Sting Allergy

Mahidol University

Status: Completed

Conditions: Insect Sting Allergy

Treatments: Other: Skin prick test; Other: sIgE measurement

Study type: Interventional

Funder types: Other

Identifiers

NCT02764242

Si063/2557

Details and patient eligibility

About

Study the causative insect by skin prick test and sIgE to wasp, bee and fire ants are important but false positive by crossreactivity can occur. sIgE to recombinant venom allergen is proposed to help in finding the causative insect.

Full description

Insect sting allergy from insects in Hymenoptera is not uncommon. The reaction maybe very severe and life threatening. To find the cause of insect sting allergy is important in prevention and specific treatment such as immunotherapy. The skin prick test and sIgE of these insects may have cross reactions so it is difficult to be interpreted.

The usage of sIgE recombinant venom allergen can benefit in separate cross reaction and dual allergy reaction.

Enrollment: 20 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cases with severe insect sting allergy reactions

Exclusion criteria

• Without other severe systemic diseases
• Not pregnant or lactation

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

insect sting allergy

Other group

Description:

Skin prick tests to local and imported insect sting allergen with different concentration are performed. sIgE Measurement (to insect and the recombinant venom)

Treatment:

Other: Skin prick test

Other: sIgE measurement