The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.

Northumbria University

Status: Completed

Conditions: Hypoxia, Altitude; Brain

Treatments: Other: Placebo; Dietary Supplement: Resveratrol

Study type: Interventional

Funder types: Other

Identifiers

NCT03541993

42AX2

Details and patient eligibility

About

Background: Vaso-active polyphenols have been proposed to enhance cognitive performance. Oral administration with the non-flavonoid polyphenol, resveratrol, has been found to modulate cerebral blood flow (CBF); yet, this has not resulted in subsequent predicted benefits to cognitive performance in young, healthy samples. It has been argued that ageing populations who are noted suffer a reduction in CBF and cognition, may possess the subtle deficits to benefit from resveratrol administration. The use of hypoxia has been previously tested by this research group to mimic the decrease in cognitive functioning associated with ageing.

Objectives: The current investigation aimed to further assess if a reduced fraction of inspired oxygen (12.7% FiO2) could provide an experimental model of aging in a young, healthy sample. Moreover, the current study also aimed to assess if resveratrol can attenuate the deficits elicited by the reduction in oxygen supply via increased CBF.

Design: This repeated measures, double blind, placebo controlled, balanced design assessed the cognitive and CBF effects of resveratrol in hypoxia (equivalent to 4000 m above sea level) and normoxia (sea level).

Methods: Twenty-four participants arrived fully fasted (except water) for 12 hours before completing a baseline measure of a cognitive task battery, and taking the treatment for the day (either 500 mg resveratrol or inert placebo). Following a 45 min absorption period, participants completed 3 full repetitions of a cognitive test battery. Changes in cerebral hemodynamics were measured by near-infrared spectroscopy throughout the full testing session.

Enrollment: 24 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Individuals who provided informed consent.
• Those who didn't meet any of the exclusion criteria.
• Those who took hormonal contraception (e.g.: the pill, coil, implant, etc.) were eligible to participate in the current study.

Exclusion criteria

• Individuals below 18 years or above 35 years old at the time of giving consent.
• Individuals with Body Mass Index outside of the range 18-35 kg/m2.
• Individuals with blood pressure greater than 140/90 HH/mg.
• Those who smoke or have smoked.
• Individuals who have been living (for more than 3 months) at an altitude of 2000 m or over within the past 6 months.
• Individuals with a history of neurological, vascular or psychiatric illness (excluding depressive illness and anxiety).
• Individuals with a current diagnosis of depression and/or anxiety.
• Individuals with relevant learning difficulties, dyslexia, dyscalculia or colour blindness.
• Individuals with visual impairment that cannot be corrected with glasses or contact lenses.
• Individuals with frequent migraines that require medication (more than or equal to 1 per month).
• Individuals with disorders of the blood.
• Individuals with a heart disorder.
• Individuals with a respiratory disorder that requires regular medication (Note: asthma sufferers who only take their medication occasionally/as required are eligible for this study).
• Individuals with diabetes.
• Individuals with any food intolerances/sensitivities.
• Females participants who were pregnant, seeking to become pregnant, or currently lactating.
• Individuals currently taking any prescription medications.
• Individuals who have habitually used dietary supplements within the last month (defined as more than 3 consecutive days or 4 days in total).
• Individuals with a history of renal or hepatic disease, or other severe diseases of the gastrointestinal tract (e.g., iron accumulation, iron utilization disorders, hypercalcaemia, hypercalciuria), that are likely to interfere with metabolism/absorption/secretion of the product under investigation.
• Individuals with any health condition that would prevent fulfilment of the study requirements.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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24 participants in 4 patient groups, including a placebo group

Resveratrol Hypoxia

Experimental group

Description:

500 mg of trans-resveratrol, tested at a 12.7% atmospheric oxygen level; the equivalent to 4000m above sea level.

Treatment:

Dietary Supplement: Resveratrol

Placebo Hypoxia

Placebo Comparator group

Description:

Pharmaceutical grade fumed silica, tested at a 12.7% atmospheric oxygen level; the equivalent to 4000 m above sea level.

Treatment:

Other: Placebo

Resveratrol Normoxia

Experimental group

Description:

500 mg of trans-resveratrol, tested at a 20.9% atmospheric oxygen level; the equivalent to sea level.

Treatment:

Dietary Supplement: Resveratrol

Placebo Normoxia

Placebo Comparator group

Description:

Pharmaceutical grade fumed silica, tested at a 20.9% atmospheric oxygen level; the equivalent to sea level.

Treatment:

Other: Placebo