The Change of Gut Microbiota After Bowel Preparation and the Effect of Probiotics

Kosin University Gospel Hospital

Status and phase: Completed; Phase 2

Conditions: Gut Microbiota; Colonoscopy; Bowel Preparation

Treatments: Drug: Duolac

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03760133

2018-07-024

Details and patient eligibility

About

The purpose of this study is to investigate the relationship between the change of intestinal bacterial flora and the recovery, and the incidence of symptoms such as abdominal discomfort after colonoscopy. And the investigators will also analyze the effects of probiotics on the degree of change, recovery, and symptom development in intestinal flora.

Full description

The investigators divided two groups. (total number = 100 subjects)

1. with probiotics group - 50 subjects

   • Participants included in this group will be taken probiotics for 1 month after bowel preparation for colonoscopy.

2. without probiotics group - 50 subjects

   • Participants included in this group will not be taken probiotics for 1 month after bowel preparation for colonoscopy.

Enrollment: 100 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adults between the age of 30 and 70

Exclusion criteria

• subjects with cancer or IBD (inflammatory bowel disease)
• subjects with history of abdominal surgery
• subjects who take medication related to gastrointestinal motility within 3 months
• subjects who take antibiotics within 3 months

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

with Probiotics

Active Comparator group

Description:

Participants included in this group will be taken probiotics for 1 month after bowel preparation for colonoscopy.

Treatment:

Drug: Duolac

without Probiotics

No Intervention group

Description:

Participants included in this group will not be taken probiotics for 1 month after bowel preparation for colonoscopy.