The Change of the Tetanus Antibody Titer After Single Injection of Td and Simultaneous Injection of TIG With Td
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The investigators want to determine whether TIG influences the formation of tetanus antibody after simultaneous tetanus vaccination according to age and the time-interval of the last tetanus vaccination.
Full description
When an injured patient visits the ED, unnecessary injection of tetanus immunoglobulin (TIG) may cause side effects and also increase the medical expense.5 Further, the opportunity of assessing a rising tetanus antibody titer may be missed after simultaneous injection of tetanus-diphtheria vaccine (Td) and TIG. According to age, the elevation of the tetanus antibody titer after tetanus prophylaxis might be not equivalent because of different levels of basal immunity and the time-interval of the last tetanus vaccination. Therefore, we wanted to determine whether TIG influences the formation of tetanus antibody after simultaneous tetanus vaccination according to age and the time-interval of the last tetanus vaccination.
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Volunteers
Inclusion criteria
- healthy adult volunteers
Exclusion criteria
- immunocompromised
- febrile
- allergy to the vaccine constituents
- previous tetanus immunization within 5 years
- medical and non-medical employees
Trial design
250 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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