The Change of Tissue Oxygen Saturation Following Volatile Anesthesia

P

Pusan National University

Status

Completed

Conditions

Aging
Healthy

Treatments

Drug: Desflurane
Device: Near-infrared spectroscopy monitor

Study type

Observational

Funder types

Other

Identifiers

NCT03060798
1607-012-054

Details and patient eligibility

About

General anesthesia can affect tissue oxygen saturation and microcirculatory reactivity. However, the differences in microcirculation caused by anesthetic methods have not been well studied. Near-infrared spectroscopy (NIRS) measures peripheral tissue oxygen saturation noninvasively and can be used in conjunction with vascular occlusion (VOT) experiments. The purpose of this study was to examine the changes in NIRS derived tissue oxygen saturation (StO2) and microcirculatory reactivity by VOT after inhalation anesthesia in healthy population. This prospective, observational study will be performed on 60 healthy patients who had undergone elective surgery under volatile general anesthesia. The investigators measure StO2 and microvascular reactivity using NIRS combined with vascular occlusion test (VOT). The parameters were performed twice per patient, before and after the induction of anesthesia. Occlusion slope and recovery slope during VOT will be compared before and after anesthesia. Moreover, the changes depend on the age will be analyzed.

Full description

This prospective observational study was performed on 60 patients without comorbidities who underwent elective surgery under general anesthesia. Before and after the induction of anesthesia, StO2 monitoring and VOT were performed to investigate the effect of anesthesia on microcirculation. To investigate the effect of age on microcirculation, the patients were divided into two different groups, young (< 65 yrs) and old (> 65 yrs) groups, and the VOT-derived parameters and hemodynamics between two groups were compared.

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult Over 18 years of age undergoing general surgery under general anesthesia.

Exclusion criteria

ASA category III or IV, Diabetes, Chronic Kidney Disease, Vascular Disease

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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