The Clinical and Laboratory Phenotypes of Severe Asthma Patients in Clalit Health Services Haifa

Israel Healthcare Foundation

Status: Withdrawn

Conditions: Asthma

Treatments: Other: Severe Asthma

Study type: Observational

Funder types: Other

Identifiers

NCT01741805

CMC-12-0032-CTIL

Details and patient eligibility

About

Asthma is a chronic illness characterized by inflammation of the airways. Severe asthma is defined in the literature as asthma not controlled by medication. In recent years it has become known that severe asthma is a variable disease and has subtypes relating to the age of onset, type of inflammation and allergy, obesity, etc.

Our aim is to characterize the phenotypes of severe asthma population in our clinic and compare the prevalent phenotypes to the phenotypes described before.

Full description

Study measures will include the following:

• asthma demographic and symptoms questionnaire
• Validation of proper inhaler technique
• Height, weight measurements
• Forced spirometry and reversibility testing
• DLCO
• Fractional excretion of NO in exhaled breath
• Chest and sinus CT
• Induced sputum analysis
• Complete blood count, electrolytes, immunoglobulin E, Aspergillus Specific IgE
• Skin allergy testing

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Presence of Asthma- typical symptoms and signs accompanied by either: a. obstruction in Spirometry, OR- b. positive methacholine test
2. Regular use of high dose of inhaled corticosteroids (1000 micrograms of fluticasone per day or equivalent) in addition to a long acting beta agonist (LABA).
3. Lack of asthma control- 2 or more exacerbations in the past year- exacerbations defined by hospitalization or care in an emergency department or treatment with systemic glucocorticosteroids for exacerbation of asthma symptoms.

Exclusion criteria

1. Presence of another relevant respiratory illness, such as chronic obstructive pulmonary disease (COPD)
2. lack of adherence to medical therapy

Trial design

0 participants in 1 patient group

Severe Asthma

Description:

Patients with severe asthma as specified under inclusion, exclusion criteria

Treatment:

Other: Severe Asthma