The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis

Yonsei University Health System (YUHS)

Status: Completed

Conditions: Choledocholithiasis

Study type: Observational

Funder types: Other

Identifiers

NCT02647593

3-2012-0165

Details and patient eligibility

About

Laboratory change induced by common bile duct (CBD) stone is in general observed as the higher elevation of alkaline phosphatase (ALP) and gamma-glutamyl transpeptideas (ɤ-GT), in comparison to those of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). However, some patients with CBD stone show the marked increased level of aminotransferase, which sometimes leads to misdiagnose those as liver disease caused by viral hepatitis, ischemia, and drug toxicity. The aim of this study is to investigate the clinicopathologic features of patients with CBD stones with the high level of aminotransferase in serum.

Enrollment: 44 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients were diagnosed with CBD stone under endoscopic retrograde cholangiopancreatography (ERCP)
2. patients showing above 400 IU/L of aminotransferase when at the first admitted into hospital and the control groups is the patients displaying normal AST and ALT.

Exclusion criteria

• 1. underlying hepatobiliary disease 2. alcoholics 3. cholangitis

Trial design

44 participants in 2 patient groups

gallstone hepatitis group,

Description:

gallstone hepatitis group (Among patients diagnosed as CBD stone who displayed above 400 IU/L of aminotransferase without cholangitis),

control group

Description:

control group (Among patients diagnosed as CBD stone who showed the normal value of aminotransferase)