The Clinical Significance of the Uncinate Process Histopathology in Chronic Rhinosinusitis

A

Assuta Hospital Systems

Status

Unknown

Conditions

Rhinosinusitis

Study type

Observational

Funder types

Other

Identifiers

NCT01296919
AssutaHS10-2010037

Details and patient eligibility

About

Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that inflammation of the uncinate process is associated with decreased ventilation and drainage of the paranasal sinuses and consequently with the inflammatory process occuring in the sinuses.

Full description

The purpose of the present study is to gain insight into the histopathological changes of the uncinate process in patients with chronic rhinosinusitis through comparison of its mucosal and bony elements with those of the normal uncinate process without chronic inflammation (unpublished data: Gilead Berger, Ephraim Eviatar, Tatiana Kogan, Roee Landsberg).

Enrollment

30 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with chronic rhinosinusitis who:

  • Failed conservative medical treatment.
  • Stopped treatment (topical or systemic corticosteroids) at least two months before endoscopic sinus surgery.
  • Had a Lund-MacKay CT score of 2 and higher of 24 available.

Exclusion criteria

  • Immunosuppressed patients.
  • Patients in whom a pathologic evaluation of the middle turbinate was necessary (e.g., suspected neoplastic disorder).
  • Patients with a Lund-MacKay CT score < 2 of 24 available.
  • Pregnant women.
  • Patients who underwent prior endoscopic sinus surgery.

Trial design

30 participants in 1 patient group

Sinus drainage
Description:
Adult patients with chronic rhinosinusitis who failed treatment with antibiotics and topical corticosteroids and underwent endoscopic sinus surgery. Preoperative evaluation included paranasal sinus CT scans. The diagnosis was confirmed by endoscopic examination showing purulent and/or mucopurulent discharge in the middle and/or superior meatus.

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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